climatic droplet keratopathy and pterygium was examined in a group of Climatic droplet keratopathy was seen especially in aboriginal males who had worked. PDF | On Jan 1, , Khalid F Tabbara and others published Climatic Droplet Keratopathy. The band-shaped bilateral corneal opacities that sometimes develop in certain geographically defined parts of the world are characterized by the deposition of.

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Tears also have among different components that prevent oxidative stress drpolet constant level of AA which is maintained by the lachrymal gland and not by the cornea [ 5760 ].

Tears contain many identifiable proteins [ 45 ], with the variation in their composition possibly defining biomarkers that could lead to a better understanding of the underlying pathology [ 46 ].

Climatic droplet keratopathy: an old disease in new clothes.

Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate.

The twenty-five CDK patients manifested they worked outdoors in sheep farming, never used eye protection, had a very restricted diet as previously shown during their life, and had the lowest AAs concentration. Men are affected more than women.

Climatic droplet keratopathy.

Create a free personal account to dtoplet free article PDFs, sign up for alerts, customize your interests, and more. When lesions involve the central cornea, patients may experience reduced visual acuity. The epithelium and basement membrane are affected only in advanced stages, during which the Bowman membrane is often disrupted or absent locally.


Usually, inflammatory cells are absent. Given that CDK is a chronic disease of slow evolution, we should had made all these measurements for many consecutive years in the four extremely isolated Argentinean regions we investigated, which was certaintly an unfeasible task.

Climatic Droplet Keratopathy: II. Pathologic Findings | JAMA Ophthalmology | JAMA Network

Similar results were obtained when corneal epithelial cells were exposed to UVR in vitro [ 4849 ]. The study sample was composed of 89, and individuals for regions 1, 2, 3, and 4, respectively. Enroll in the Residents and Fellows contest. Climatic droplet keratopathy CDK is an acquired and potentially handicapping cornea degenerative disease that is highly prevalent dfoplet certain rural communities around the world.

To infer causality, it is necessary to conduct field studies to assess the individual dose-response to UVR.

As can be seen clijatic Table 3 the majority of individuals from this region who do not suffer CDK have the same work activity and habits. Assigned status Up to Date by Danny A. The coalescence and increased volume of these spherules may cause the disruption of Bowman’s membrane and the elevation and thinning of the corneal epithelium. Increasing age and exposure to ultraviolet light are the most common associated risk factors. Due to possible reduced corneal sensation because of the deposits, sterile ulcerations may progress to microbial keratitis or perforate rapidly.

This report shows that such corneal disease occurs more frequently than has been suspected and suggests ultraviolet irradiation as a common etiogenic factor. It should also be borne in mind that regions 1, 2, and 3 are characterized by the presence of extensive areas devoid of shadows.


Pinguecula prevalence was significantly higher than pterygium for regions 1, 2, and 3, but not for dropplet 4. CDK has been defined as a rural disease in which the clinical presentation and severity of corneal injuries can vary significantly depending on the region and its weather.

Climatic droplet keratopathy: an old disease in new clothes.

Geographical and Climatic Characteristics of the Regions Figure 1 shows the different regions studied. The estimation of UVR dose reaching the eyes is also very important in order to be able to determine its harmful effects.

Percentages of pterygium and pinguecula in the four regions of Argentina. View at Google Scholar.

Elevated lesions may progress to complications such as epithelial defects, recurrent corneal erosions, or sterile ulceration. Retrieved from ” http: The severity of this disease can be classified in three stages, according to the portion of cornea involved and the clinical aspects: All the individuals work outdoors during the greater part of the day. CDK is characterized by the haziness and opalescence of the cornea’s most anterior layers which go through three stages with increasing severity.

View at Google Scholar S.